Version: 8.0.0Date: Tue Jan 28 2025
Gene
brd-1
- Species
- Caenorhabditis elegans
- Symbol
- brd-1
- Name
- BaRD homolog (tumor suppressor gene Bard1) 1
- Synonyms
- CELE_K04C2.4
- K04C2.4
- Biotype
- protein coding gene
- Automated Description
- Enables ubiquitin protein ligase activity. Involved in DNA repair and protein ubiquitination. Part of BRCA1-BARD1 complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1).
- WB Description
- brd-1 encodes an ortholog of the BRCA1-associating protein BARD1(OMIM:601593), associated with susceptibility to breast cancer; BRD-1forms a heterodimer with BRC-1, which constitutes an E3 ubiquitin ligase;after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 arerequired for BRC-1/BRD-1 heterodimers to associate with the E2ubiqutin-conjugating enzyme LET-70/Ubc5 and with RAD-51, and toubiquitylate damaged chromatin; BRD-1 and BRC-1 bind one another, probablythrough their N-terminal RING domains, in yeast two-hybrid experiments andpull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 andother proteins via mutual binding to UBC-9; brd-1(RNAi) animals haveexcess chromosomal nondisjunction, abnormally high levels ofCEP-1-dependent germ cell apoptosis (both with and withoutgamma-irradiation) and hypersensitivity to gamma-irradiation (e.g.,abnormal sterility after irradiation); BRD-1 autoubiquitylation probablyactivates the BRC-1/BRD-1 heterodimer; BRD-1 binds SMT-3 (a Sumo homolog)and TAC-1; brd-1 is genetically dispensable for the induction of nuclearATL-1 foci by gamma-irradiation or hydroxyurea.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24132
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIII:6885207...6889504 - (4.30 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.