Version: 8.0.0
Date: Tue Jan 28 2025
cat-2
Caenorhabditis elegansWB:WBGene00000296
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

cat-2

Species
Caenorhabditis elegans
Symbol
cat-2
Name
abnormal CATecholamine distribution 2
Synonyms
  • B0432.5
  • CELE_B0432.5
Biotype
protein coding gene
Automated Description
Enables tyrosine 3-monooxygenase activity. Involved in several processes, including cellular response to amphetamine; dopamine biosynthetic process from tyrosine; and male mating behavior. Located in axon. Is expressed in dopaminergic neurons; socket cell; and in male. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; heroin dependence; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
WB Description
cat-2 encodes a tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of catecholamines, such as dopamine; mutations in cat-2 affect dopamine levels that in turn affect locomotory slowing in response to food; CAT-2 demonstrates tyrosine hydroxylase activity in vitro, and this activity can be regulated, in vitro, by phosphorylation of CAT-2 Ser35 by protein kinase A; CAT-2 activity does not appear, however, to be regulated by other mechanisms, including substrate inhibition or feedback inhibition; cat-2 is expressed in dopaminergic as well as other neurons, male spicules, and male ray neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11473
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            258.0k258.5k259.0k259.5k260.0k260.5k261.0k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            cat-2 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              cat-2 role
              cat-2 genetic perturbation
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