Version: 8.0.0
Date: Tue Jan 28 2025
casy-1
Caenorhabditis elegansWB:WBGene00000403
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

casy-1

Species
Caenorhabditis elegans
Symbol
casy-1
Name
CAlSYntenin/Alcadein homolog 1
Synonyms
  • B0034.3
  • cdh-11
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including neuromuscular junction; neuronal cell body membrane; and synaptic cleft. Is expressed in gonadal sheath cell; intestine; and nervous system. Orthologous to several human genes including CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3).
WB Description
casy-1 encodes a type I transmembrane protein with two extracellular cadherin domains and an LG/LNS domain that is the sole C. elegans calsyntenin/alcadein ortholog; genetic studies indicate that in C. elegans casy-1 activity is required, in parallel to the insulin-like signaling pathway, for several types of learning, including salt chemotaxis learning, temperature learning, olfactory adaptation, and integration of two sensory stimuli; large-scale RNAi experiments also suggest that casy-1 plays a role in embryonic development; casy-1 expression in adult animals is able to rescue salt chemotaxis learning defects, indicating that CASY-1 function in mature animals is sufficient to effect proper chemotactic behavior; in addition, CASY-1 expression in the ASER neuron, but not other neurons, rescues salt chemotaxis learning defects, indicating the CASY-1 can act solely in this chemosensory neuron for normal salt chemotaxis learning; a casy-1::GFP promoter fusion is expressed throughout the nervous system, including the head amphid sensory neurons, with additional expression seen in the intestine and gonadal sheath cells; a CASY-1::GFP protein fusion localizes to the plasma membrane and intracellular membranes of neuronal cell bodies, with specific N-terminal fusions indicative of CASY-1 ectodomain release into the extracellular space; domain-specific rescue experiments indicate that the secreted, proteolytically processed CASY-1 extracellular domain is sufficient to rescue salt chemotaxis learning defects.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14139
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.946M5.947M5.948M5.949M5.950M5.951M5.952M5.953M5.954M5.955M5.956M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            casy-1 molecule type
            Interactor gene
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            Interactor molecule type
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              Genetic Interactions

              casy-1 role
              casy-1 genetic perturbation
              Interactor gene
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