Predicted to enable DNA-binding transcription factor activity. Involved in cell-cell adhesion and embryo development. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic cell; hypodermal cell; neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Orthologous to several human genes including HOXB1 (homeobox B1) and HOXD1 (homeobox D1).
WB Description
a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae.