Version: 8.0.0
Date: Tue Jan 28 2025
ceh-34
Caenorhabditis elegansWB:WBGene00000455
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ceh-34

Species
Caenorhabditis elegans
Symbol
ceh-34
Name
C. Elegans Homeobox 34
Synonyms
  • C10G8.6
  • CELE_C10G8.6
Biotype
protein coding gene
Automated Description
Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of apoptotic process involved in development; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in body wall musculature; head; male sex myoblast; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; nephroblastoma; and renal Wilms' tumor. Orthologous to human SIX1 (SIX homeobox 1) and SIX2 (SIX homeobox 2).
WB Description
ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994); ceh-34 activity is required for regulation of the programmed cell death of a pharyngeal neuron, the sister of the M4 motor neuron; CEH-34 binds the egl-1 5'-regulatory region in vitro and acts together with EYA-1, with which it physically interacts, to regulate expression of egl-1 to promote programmed cell death of the M4 sister; CEH-34 and EYA-1 also function together, downstream of the Wnt signaling pathway, to regulate non-muscle cell fate specification in the postembryonic mesoderm; a ceh-34::gfp fusion is expressed predominantly in pharyngeal cells with some expression also seen in anterior body wall muscles near the pharynx and also in the coelomocyte precursors; CEH-34::GFP localizes to nuclei.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10390
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.3155M5.3160M5.3165M5.3170M5.3175M5.3180M5.3185M5.3190M5.3195M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ceh-34 molecule type
            Interactor gene
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              Genetic Interactions

              ceh-34 role
              ceh-34 genetic perturbation
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