Gene

ces-2

Species
Caenorhabditis elegans
Symbol
ces-2
Name
CEll death Specification 2
Synonyms
  • CELE_ZK909.4
  • ZK909.4
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including apoptotic process; positive regulation of programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in excretory duct cell. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human DBP (D-box binding PAR bZIP transcription factor); HLF (HLF transcription factor, PAR bZIP family member); and TEF (TEF transcription factor, PAR bZIP family member).
WB Description
ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor, most similar in sequence and binding specificity to the PAR (proline- and acid-rich) subfamily of bZIP proteins; ces-2 is required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons, and is transcriptionally inhibited by activated LET-60(G12V); in regulating programmed cell death in the NSM sister cell, CES-2 functions together with DNJ-11 to negatively regulate transcription of ces-1 which, in turn, negatively regulates transcription of the pro-apoptotic BH3-only gene egl-1; ces-2 also functions together with dnj-11 to regulate asymmetric cell division and mitotic spindle orientation in the NSM lineage, revealing a functional coupling between asymmetric cell division and apoptosis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11988
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
14.9615M14.9620M14.9625M14.9630M14.9635M14.9640M14.9645M14.9650M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions