Version: 8.0.0
Date: Tue Jan 28 2025
cki-2
Caenorhabditis elegansWB:WBGene00000517
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

cki-2

Species
Caenorhabditis elegans
Symbol
cki-2
Name
CKI family (Cyclin-dependent Kinase Inhibitor) 2
Synonyms
  • CELE_T05A6.2
  • T05A6.2
Biotype
protein coding gene
Automated Description
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in gonad development; regulation of cell cycle process; and regulation of cell division. Predicted to be located in nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Beckwith-Wiedemann syndrome; IMAGe syndrome; hematologic cancer (multiple); hyperinsulinism; and multiple endocrine neoplasia type 4. Orthologous to several human genes including CDKN1B (cyclin dependent kinase inhibitor 1B).
WB Description
cki-2 encodes a cyclin-dependent kinase (CDK) inhibitor of the CIP/KIP family, orthologous to human CDKN1C (OMIM:600856, which when mutated leads to Beckwith-Wiedemann syndrome) that may play a role in cell cycle progression during embryogenesis; CKI-2 interacts with PCN-1, a proliferating cell nuclear antigen homolog, SMO-1, a SUMO (ubiquitin related) homolog, and the RING domain-containing protein C06A5.9.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10265
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          cki-2 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            cki-2 role
            cki-2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
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