Gene

clp-1

Species
Caenorhabditis elegans
Symbol
clp-1
Name
CaLPain family 1
Synonyms
  • C06G4.2
  • CELE_C06G4.2
Biotype
protein coding gene
Automated Description
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to calcium ion; muscle cell cellular homeostasis; and positive regulation of sarcomere organization. Located in M band. Is expressed in several structures, including body wall musculature; egg-laying apparatus; intestine; nervous system; and pharynx. Used to study Duchenne muscular dystrophy and hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; muscular dystrophy; and stomach cancer. Orthologous to several human genes including CAPN3 (calpain 3) and CAPN9 (calpain 9).
WB Description
clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10183
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Sequence Details

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          Expression

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          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

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            Genetic Interactions

            clp-1 role
            clp-1 genetic perturbation
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