Version: 8.0.0
Date: Tue Jan 28 2025
cog-1
Caenorhabditis elegansWB:WBGene00000584
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

cog-1

Species
Caenorhabditis elegans
Symbol
cog-1
Name
Connection Of Gonad defective 1
Synonyms
  • CELE_R03C1.3
  • R03C1.3
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor binding activity. Involved in several processes, including determination of left/right symmetry; neuron development involved in amphid sensory organ development; and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including anal sphincter muscle; egg-laying apparatus; ganglia; male-specific anatomical entity; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to several human genes including NKX6-1 (NK6 homeobox 1) and NKX6-2 (NK6 homeobox 2).
WB Description
cog-1 encodes the C. elegans ortholog of the vertebrate Nkx6 homeodomain proteins; cog-1 activity is required for multiple aspects of reproductive system development, including connection of uterus to the vulva and vulval cell specification, as well as for specification of left/right asymmetry in the ASE taste receptor sensory neurons where cog-1 acts in ASER to suppress the ASEL cell fate; cog-1 expression in ASEL is negatively regulated by the lsy-6 miRNA; a cog-1::gfp reporter fusion is expressed in neurons and in the hermaphrodite vulva and uterus; in males, cog-1::gfp expression is seen in proctodeal cells and occasionally in the rectal Rep cells and P11.pp progeny.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24340
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          cog-1 molecule type
          Interactor gene
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            Genetic Interactions

            cog-1 role
            cog-1 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
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            Phenotype or trait
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