Version: 8.0.0Date: Tue Jan 28 2025
Gene
csk-1
- Species
- Caenorhabditis elegans
- Symbol
- csk-1
- Name
- C-terminal Src Kinase 1
- Synonyms
- CELE_Y48G1C.2
- Y48G1C.2
- Biotype
- protein coding gene
- Automated Description
- Enables protein tyrosine kinase activity. Involved in several processes, including larval feeding behavior; nematode larval development; and nematode pharyngeal pumping. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including anus; head neurons; hermaphrodite somatic gonadal cell; pharyngeal muscle cell; and vulval cell. Orthologous to several human genes including CSK (C-terminal Src kinase).
- WB Description
- csk-1 encodes an ortholog of C-terminal Src kinase (Csk) that probablyinhibits SRC-like tyrosine kinases in pharyngeal muscle cells; theC-terminal tyrosines of the SRC-like kinases SRC-2/KIN-22 and SRC-1 areevolutionarily conserved, and phosphorylated by CSK-1, which inhibitsSRC-2/KIN-22 and SRC-1 in vivo; csk-1 is co-expressed with src-2/kin-22 and src-1 inpharyngeal procorpus and metacorpus; csk-1(RNAi) animals are grosslynormal, but overexpression of csk-1 induces an abnormal pharyngealphenotype.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24418
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:71425...81156 + (9.73 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.