Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cell cycle; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in intestine; muscle cell; and neurons. Orthologous to human CUL1 (cullin 1).
WB Description
cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10).