Version: 8.0.0
Date: Tue Jan 28 2025
cyb-3
Caenorhabditis elegansWB:WBGene00000868
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

cyb-3

Species
Caenorhabditis elegans
Symbol
cyb-3
Name
CYclin B 3
Synonyms
  • CELE_T06E6.2
  • cyb-2
Biotype
protein coding gene
Automated Description
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including chromosome organization; positive regulation of mitotic metaphase/anaphase transition; and pronuclear migration. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including AB; EMS; Psub1; germ line; and gonad. Orthologous to human CCNB3 (cyclin B3).
WB Description
cyb-3 encodes one of four C. elegans cyclin B family members that is most closely related to the B3-type cyclins; cyb-3 is required for a number of dynein-related mitotic processes and specifically for initiation of anaphase chromosome segregation; cyb-3 is also required for completion of meiosis II and proper pronuclear migration, centrosome maturation, and pronuclear condensation in the fertilized oocyte; cyb-3 is also essential for embryonic viability.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10177
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          cyb-3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            cyb-3 role
            cyb-3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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