Gene

cyn-7

Species
Caenorhabditis elegans
Symbol
cyn-7
Name
CYclophyliN 7
Synonyms
  • CELE_Y75B12B.2
  • cyp-7
Biotype
protein coding gene
Automated Description
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F).
WB Description
cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11071
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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15.1866M15.1867M15.1868M15.1869M15.1870M15.1871M15.1872M15.1873M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions