Version: 8.0.0
Date: Tue Jan 28 2025
daf-7
Caenorhabditis elegansWB:WBGene00000903
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

daf-7

Species
Caenorhabditis elegans
Symbol
daf-7
Name
abnormal DAuer Formation 7
Synonyms
  • B0412.2
  • CELE_B0412.2
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to cGMP; regulation of gene expression; and response to bacterium. Located in extracellular space. Is expressed in coelomocyte; neurons; pharynx; and in male. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy and vertebral hypersegmentation and orofacial anomalies. Orthologous to several human genes including GDF11 (growth differentiation factor 11).
WB Description
daf-7 encodes a member of the transforming growth factor beta superfamily; in C. elegans, DAF-7 functions as part of a signaling pathway that interprets environmental conditions to regulate energy-balance pathways that affect dauer larval formation, adult lifespan, fat metabolism, egg laying, pathogen avoidance behavior, and feeding behavior; daf-7 reporter gene fusions are expressed in the ASI, ADE, and OLQ neurons, and daf-7 expression is induced in both ASI and ASJ chemosensory neurons in response to the pathogenic bacterial strain Pseudomonas aeruginosa PA14.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11848
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            daf-7 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              daf-7 role
              daf-7 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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