Version: 8.0.0
Date: Tue Jan 28 2025
hsp-90
Caenorhabditis elegansWB:WBGene00000915
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

hsp-90

Species
Caenorhabditis elegans
Symbol
hsp-90
Name
Heat Shock Protein 90
Synonyms
  • C47E8.5
  • CELE_C47E8.5
Biotype
protein coding gene
Automated Description
Enables several functions, including ATP hydrolysis activity; nuclear glucocorticoid receptor binding activity; and protein phosphatase 5 binding activity. Involved in several processes, including determination of adult lifespan; protein export from nucleus; and protein stabilization. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in several structures, including excretory system; germ line; head; intestine; and pharynx. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1).
WB Description
daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11528
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          hsp-90 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            hsp-90 role
            hsp-90 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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