Gene

dhs-2

Species
Caenorhabditis elegans
Symbol
dhs-2
Name
DeHydrogenases, Short chain 2
Synonyms
  • CELE_F55A12.4
  • F55A12.4
Biotype
protein coding gene
Automated Description
Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Orthologous to several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH16 (retinol dehydrogenase 16).
WB Description
dhs-2 encodes a short-chain dehydrogenase predicted to be mitochondrial.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43313
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensRDH168 of 9YesYes   
Homo sapiensRDH58 of 9YesNo   
Homo sapiensHSD17B68 of 9YesNo   
Homo sapiensSDR9C78 of 9YesNo   
Homo sapiensDHRS98 of 9YesNo   
Mus musculusHsd17b67 of 9YesNo   
Mus musculusDhrs97 of 9YesNo   
Rattus norvegicusDhrs97 of 9YesNo   
Rattus norvegicusHsd17b67 of 9YesNo   
Xenopus tropicalisrdh77 of 9YesYes   
Xenopus tropicalisXB59572207 of 9YesYes   
Xenopus tropicalisrdh166 of 9YesYes   
Xenopus tropicalisrdh16.26 of 9YesYes   
Xenopus tropicalisrdh7.26 of 9YesNo   
Xenopus tropicalisdhrs95 of 9NoYes   
Xenopus tropicalisrdh16.34 of 9NoYes   
Xenopus tropicalisrdh53 of 9NoYes   
Xenopus tropicalishsd17b63 of 9NoYes   
Danio reriodhrs98 of 9YesYes   
Danio reriordh17 of 9NoYes   
Drosophila melanogasterCG88886 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
dhs-20133260416 of 8  
dhs-16233356436 of 8  
drd-5333959405 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
shortened life span
Showing 1 - 1 of 1 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
tm7516allele with one associated variant
deletion
  • splice acceptor variant
Yes
NC_003279.8:g.5356595T>Avariant
SNP
  • intron variant
NC_003279.8:g.5355053C>Tvariant
SNP
  • missense variant
NC_003279.8:g.5354708C>Tvariant
SNP
  • intron variant
NC_003279.8:g.5354364T>Gvariant
SNP
  • synonymous variant
NC_003279.8:g.5355913G>Avariant
SNP
  • intron variant
NC_003279.8:g.5355796G>Avariant
SNP
  • missense variant
NC_003279.8:g.5356013G>Avariant
SNP
  • intron variant
NC_003279.8:g.5356429G>Avariant
SNP
  • intron variant
NC_003279.8:g.5355450A>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 30 rows
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.3545M5.3550M5.3555M5.3560M5.3565M5.3570M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available