Version: 8.0.0
Date: Tue Jan 28 2025
dlk-1
Caenorhabditis elegansWB:WBGene00001008
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

dlk-1

Species
Caenorhabditis elegans
Symbol
dlk-1
Name
Dual-Leucine zipper Kinase 1
Synonyms
  • CELE_F33E2.2
  • F33E2.2
Biotype
protein coding gene
Automated Description
Enables ubiquitin protein ligase binding activity. Involved in several processes, including p38MAPK cascade; regulation of axon extension; and sprouting of injured axon. Located in neuronal cell body and synapse. Is expressed in neurons and pharynx. Orthologous to several human genes including MAP3K12 (mitogen-activated protein kinase kinase kinase 12).
WB Description
dlk-1 encodes a mitogen-activated protein kinase kinase kinase (MAPKKK) that is the C. elegans ortholog of the dual-leucine zipper MAPKKK; in C. elegans, dlk-1 functions with mkk-4 and pmk-3 in a MAPK signaling pathway that regulates presynaptic development; dlk-1 is also essential for neuron regeneration; DLK-1 abundance is negatively regulated by the RPM-1 E3 ubiquitin ligase which can stimulate DLK-1 ubiquitination; DLK-1 localizes to the periactive zone of synapses in the nerve ring and nerve cord.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23257
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            12.566M12.567M12.568M12.569M12.570M12.571M12.572M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            dlk-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              dlk-1 role
              dlk-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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