Version: 8.0.0Date: Tue Jan 28 2025
Gene
dre-1
- Species
- Caenorhabditis elegans
- Symbol
- dre-1
- Name
- Daf-12, REdundant with 1
- Synonyms
- CELE_K04A8.6
- F46E10.a
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable zinc ion binding activity. Involved in several processes, including mesodermal cell migration; nematode larval development; and positive regulation of apoptotic process involved in development. Located in cytoplasm and nucleus. Is expressed in several structures, including P5.p hermaphrodite; alimentary muscle; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11).
- WB Description
- dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associatedwith vitiligo and otitis media) that is required, in conjunction withDAF-12 and its partners, for global developmental timing of thetransistion from larval to adult cell fates; DRE-1 has an N-terminalF-box domain, three central tandem C-terminal CASH domains, and aC-terminal zinc finger; hypomorphic dre-1 mutations are syntheticallyheterochronic with loss-of-function daf-12 alleles, inducing defectivedistal tip cell migration and precocious fusion of seam cells; fivedifferent hypomorphic dre-1 alleles alter conserved glycine residues inthe CASH domain region, whereas the null dre-1(hd60) allele is lethal atthe three-fold embryo stage; DRE-1 is expressed in many tissues,including epidermal and distal tip cells, and localizes to both nucleusand cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fedRNAi) induces defects at all four molts; dre-1 also has syntheticphenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-likeenhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), orrbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do theirhuman orthologs; DRE-1 affects lin-29 expression, and is suppressed bylin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR22990
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrV:6533614...6546500 - (12.89 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.