Gene

drh-1

Species
Caenorhabditis elegans
Symbol
drh-1
Name
Dicer Related Helicase 1
Synonyms
  • CELE_F15B10.2
  • F15B10.2
Biotype
protein coding gene
Automated Description
Predicted to enable ATP binding activity; helicase activity; and nucleic acid binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to several human genes including RIGI (RNA sensor RIG-I).
WB Description
drh-1 encodes a Dicer-related helicase that contains a DExD/H-box helicase domain; loss of drh-1 activity via RNAi suggests that drh-1 is required, perhaps redundantly with drh-2, for both germline and somatic RNA interference (RNAi); in addition, drh-1 is required, downstream of virus sensing and viral siRNA formation, for antiviral RNAi; DRH-1 interacts in vivo with RDE-4, a double-stranded RNA-binding protein required for the initiation phase of RNAi.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14074
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
drh-31113941234 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
increased susceptibility to viral infection
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Disease Associations

Cases where the expected disease association was NOT found
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Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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6.608M6.609M6.610M6.611M6.612M6.613M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions