Gene

egl-23

Species
Caenorhabditis elegans
Symbol
egl-23
Name
EGg Laying defective 23
Synonyms
  • CELE_Y37A1B.11
  • twk-41
Biotype
protein coding gene
Automated Description
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane.
WB Description
egl-23 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; egl-23 was originally defined by gain-of-function mutations that result in defects in locomotion, egg-laying, and enteric muscle activation; loss of egl-23 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that EGL-23 may function redundantly with other TWK channels; egl-23 does not, however, interact genetically with the UNC-93 group of TWKs encoded by unc-93, sup-9, and sup-10; the EGL-23 expression pattern is not yet known.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11003
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.990M13.992M13.994M13.996M13.998M14.000M14.002M14.004M14.006M14.008M14.010M14.012M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions