Gene

eps-8

Species
Caenorhabditis elegans
Symbol
eps-8
Name
EPS (human endocytosis) related 8
Synonyms
  • CELE_Y57G11C.24
  • gei-19
Biotype
protein coding gene
Automated Description
Enables actin filament binding activity. Involved in several processes, including barbed-end actin filament capping; cytoskeleton organization; and epidermis morphogenesis. Located in apical part of cell; brush border; and hemidesmosome. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102; autosomal recessive nonsyndromic deafness 106; and hypotrichosis 5. Orthologous to several human genes including EPS8L1 (EPS8 signaling adaptor L1).
WB Description
eps-8 is encodes a cell signaling adaptor protein that contains and N-terminal PTB domain, and C-terminal SH3 and actin-binding domains; EPS-8 is essential for epidermal and intestinal cells morphogenesis; eps-8 is also involved in trafficking of the LET-23 EGF receptor during vulval development; EPS-8 physically interacts with the ankyrin repeat protein VAB-19 and demonstrates a novel actin barbed-end-capping activity; EPS-8 is expressed throughout development and localizes to sites of cell-matrix attachment and to the apical side of polarized cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12287
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
14.880M14.882M14.884M14.886M14.888M14.890M14.892M14.894M14.896M14.898M14.900M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions