Version: 8.0.0
Date: Tue Jan 28 2025
eya-1
Caenorhabditis elegansWB:WBGene00001377
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

eya-1

Species
Caenorhabditis elegans
Symbol
eya-1
Name
EYA (Drosophila eyes absent) homolog 1
Synonyms
  • C49A1.4
  • CELE_C49A1.4
Biotype
protein coding gene
Automated Description
Predicted to enable protein tyrosine phosphatase activity and transcription coactivator activity. Involved in several processes, including egg-laying behavior; positive regulation of cellular response to heat; and regulation of apoptotic process. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in auditory system disease (multiple); branchiootorenal syndrome (multiple); congestive heart failure; and dilated cardiomyopathy (multiple). Orthologous to several human genes including EYA1 (EYA transcriptional coactivator and phosphatase 1); EYA2 (EYA transcriptional coactivator and phosphatase 2); and EYA3 (EYA transcriptional coactivator and phosphatase 3).
WB Description
eya-1 encodes a protein orthologous to the Eyes absent/Eya Drosophila protein which is involved in eye development and has protein tyrosine phosphatase ; RNA interference and mutant studies indicate that eya-1 is involved in embryonic and larval tissue morphogenesis as well as larval viability; eya-1 mutants show increased embryonic cell deaths due to activation of the cell death pathway; eya-1 functions redundantly with vab-3/eyeless to control larval viability and anterior body morphogenesis; GFP studies show that eya-1 is expressed in a subset of nuclei during embryonic morphogenesis; the human genes EYA1 and EYA4, when mutated, lead to disease syndromes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10190
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            14.221M14.222M14.223M14.224M14.225M14.226M14.227M14.228M14.229M14.230M14.231M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            eya-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              eya-1 role
              eya-1 genetic perturbation
              Interactor gene
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              Interactor role
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