Gene

gpa-16

Species
Caenorhabditis elegans
Symbol
gpa-16
Name
G Protein, Alpha subunit 16
Synonyms
  • CELE_Y95B8A.5
  • spn-1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Involved in embryonic axis specification and establishment of mitotic spindle orientation. Located in cell cortex. Is expressed in several structures, including AB; C; D; neurons; and pharynx. Human ortholog(s) of this gene implicated in achromatopsia 4; color blindness; congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to several human genes including GNAI1 (G protein subunit alpha i1).
WB Description
gpa-16 encodes a G protein alpha subunit; gpa-16 is required for spindle position and orientation in embryos; gpa-16 is expressed in AVM, PDE, PLM, BDU, PVC, and RIP, and weakly expressed in the pharynx, body-wall muscle, and vulval muscle.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10218
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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898k899k900k901k902k903k904k905k906k907k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions