Gene

hda-4

Species
Caenorhabditis elegans
Symbol
hda-4
Name
Histone DeAcetylase 4
Synonyms
  • C10E2.3
  • CELE_C10E2.3
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II; receptor guanylyl cyclase signaling pathway; and regulation of neuron differentiation. Located in nucleus. Is expressed in amphid neurons; body wall musculature; motor neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to several human genes including HDAC4 (histone deacetylase 4); HDAC5 (histone deacetylase 5); and HDAC7 (histone deacetylase 7).
WB Description
hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth; interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45634
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
16.730M16.732M16.734M16.736M16.738M16.740M16.742M16.744M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions