Gene

elac-2

Species
Caenorhabditis elegans
Symbol
elac-2
Name
ELAC ribonuclease ortholog 2
Synonyms
  • CELE_E04A4.4
  • E04A4.4
Biotype
protein coding gene
Automated Description
Predicted to enable 3'-tRNA processing endoribonuclease activity. Involved in several processes, including germ cell development; nematode larval development; and positive regulation of vulval development. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Is expressed in germ line. Used to study prostate cancer. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2).
WB Description
hoe-1 encodes, by alternative splicing, two isoforms of a putative metal-dependent hydrolase orthologous to human ELAC2; HOE-1 is required for fertility, normal growth progression during the late larval stages and germ line proliferation; since hoe-1(RNAi) animals do not produce gametes, hoe-1 may be required for mitosis and meiosis; hoe-1 deficiency suppresses the multivulva (Muv) phenotype of activated LET-60/RAS, while having no effect on other RAS pathway members.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12553
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.7395M4.7400M4.7405M4.7410M4.7415M4.7420M4.7425M4.7430M4.7435M4.7440M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions