Predicted to enable 3'-tRNA processing endoribonuclease activity. Involved in several processes, including germ cell development; nematode larval development; and positive regulation of vulval development. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Is expressed in germ line. Used to study prostate cancer. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2).
WB Description
hoe-1 encodes, by alternative splicing, two isoforms of a putative metal-dependent hydrolase orthologous to human ELAC2; HOE-1 is required for fertility, normal growth progression during the late larval stages and germ line proliferation; since hoe-1(RNAi) animals do not produce gametes, hoe-1 may be required for mitosis and meiosis; hoe-1 deficiency suppresses the multivulva (Muv) phenotype of activated LET-60/RAS, while having no effect on other RAS pathway members.