Version: 8.0.0
Date: Tue Jan 28 2025
hsp-3
Caenorhabditis elegansWB:WBGene00002007
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

hsp-3

Species
Caenorhabditis elegans
Symbol
hsp-3
Name
Heat Shock Protein 3
Synonyms
  • C15H9.6
  • CELE_C15H9.6
Biotype
protein coding gene
Automated Description
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum. Predicted to be part of endoplasmic reticulum chaperone complex. Predicted to be active in endoplasmic reticulum lumen; membrane; and nucleus. Is expressed in several structures, including germ line; intestine; pharyngeal gland cell; pharyngeal-intestinal valve; and tail. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5).
WB Description
hsp-3 encodes one of two C. elegans heat shock response 70 (hsp70) proteins homologous to mammalian grp78/BiP (glucose regulated protein 78/immunoglobulin heavy chain-binding protein, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; hsp-3 transcription is, however, upregulated in response to endoplasmic reticulum stress induced by dithiothreitol (DTT) or tunicamycin; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19375
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          hsp-3 molecule type
          Interactor gene
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            Genetic Interactions

            hsp-3 role
            hsp-3 genetic perturbation
            Interactor gene
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            Interactor role
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            Phenotype or trait
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