Version: 8.0.0
Date: Tue Jan 28 2025
itr-1
Caenorhabditis elegansWB:WBGene00002173
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

itr-1

Species
Caenorhabditis elegans
Symbol
itr-1
Name
Inositol Triphosphate Receptor 1
Synonyms
  • CELE_F33D4.2
  • dec-4
Biotype
protein coding gene
Automated Description
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of nematode pharyngeal pumping; and sperm ejaculation. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including epithelial cell; ganglia; gonad; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
WB Description
itr-1 encodes a putative inositol (1,4,5) trisphosphate receptor that affects the defecation cycle and pharyngeal pumping, and also affects ovulation in a pathway downstream of LET-23; interacts with UNC-54 in vivo, and is expressed in the adult intestine, pharynx, excretory cell, germ line, and spermatheca, with limited neuronal expression.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13715
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          itr-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            itr-1 role
            itr-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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