Version: 8.0.0
Date: Tue Jan 28 2025
kin-32
Caenorhabditis elegansWB:WBGene00002213
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

kin-32

Species
Caenorhabditis elegans
Symbol
kin-32
Name
protein KINase 32
Synonyms
  • C30F8.4
  • C30F8.c
Biotype
protein coding gene
Automated Description
Predicted to enable ATP binding activity and protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cellular component organization; and signal complex assembly. Predicted to be located in cell junction. Predicted to be active in dendritic spine; focal adhesion; and plasma membrane. Is expressed in body wall musculature; head mesodermal cell; head neurons; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer; hypertension; leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to several human genes including PTK2 (protein tyrosine kinase 2).
WB Description
kin-32 encodes, by alternative splicing, two isoforms of a focal adhesion kinase, orthologous to human PTK2 (OMIM:600758) and PTK2B (OMIM:601212); KIN-32 is expressed in both nuclei and cytoplasms of larval and adult bodywall muscle cells; KIN-32 is also expressed in head neurons, a head mesodermal cell, adult vulval muscle, and the reproductive system; KIN-32 has an N-terminal FERM domain, a central tyrosine kinase domain, and a divergent C-terminal focal adhesion targeting domain; KIN-32 has no obvious function, and both kin-32(RNAi) animals and kin-32(ok166) homozygotes are phenotypically normal; kin-32(ok166) probably leaves protein-kinase activity intact, and thus is likely to be only a partial loss-of-function allele.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24418
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          kin-32 molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            kin-32 role
            kin-32 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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