Gene

klp-11

Species
Caenorhabditis elegans
Symbol
klp-11
Name
Kinesin-Like Protein 11
Synonyms
  • CELE_F20C5.2
  • F20C5.2
Biotype
protein coding gene
Automated Description
Enables microtubule motor activity. Involved in microtubule-based movement. Part of axonemal heterotrimeric kinesin-II complex. Is expressed in amphid neurons; dorsal nerve cord; inner labial neurons; phasmid neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B) and KIF3C (kinesin family member 3C).
WB Description
klp-11 encodes a kinesin motor protein that functions as a subunit of C. elegans heterotrimeric kinesin-II; in vitro microtubule gliding assays demonstrate that purified kinesin-II and OSM-3, a homomeric kinesin-II motor, cooperatively generate movement similar to that seen along cilia lacking additional regulatory factors; antibodies to KLP-11 detect high intensity staining in the cilia of chemosensory neurons, with fainter staining detected in the dorsal and ventral nerve cords as well as motor commissures.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24115
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.7570M8.7575M8.7580M8.7585M8.7590M8.7595M8.7600M8.7605M8.7610M8.7615M8.7620M

            Sequence Details

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            Expression

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            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

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              Genetic Interactions

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