Gene

lem-2

Species
Caenorhabditis elegans
Symbol
lem-2
Name
LEM domain protein 2
Synonyms
  • CELE_W01G7.5
  • CeMAN1
Biotype
protein coding gene
Automated Description
Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including microtubule organizing center organization; nuclear membrane reassembly; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Orthologous to human LEMD3 (LEM domain containing 3) and LEMD2 (LEM domain nuclear envelope protein 2).
WB Description
lem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13428
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
14.0635M14.0640M14.0645M14.0650M14.0655M14.0660M14.0665M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions