Version: 8.0.0
Date: Tue Jan 28 2025
let-60
Caenorhabditis elegansWB:WBGene00002335
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

let-60

Species
Caenorhabditis elegans
Symbol
let-60
Name
LEThal 60
Synonyms
  • CELE_ZK792.6
  • lin-34
Biotype
protein coding gene
Automated Description
Enables GTP binding activity; phospholipase binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including learning or memory; positive regulation of receptor localization to synapse; and positive regulation of vulval development. Located in cell cortex. Is expressed in several structures, including gonad; head neurons; pharyngeal cell; vulval cell; and vulval precursor cell. Used to study RASopathy and cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); hematologic cancer (multiple); and high grade glioma (multiple). Orthologous to several human genes including HRAS (HRas proto-oncogene, GTPase).
WB Description
let-60 encodes a member of the GTP-binding RAS protooncogene family; let-60 activity is required for viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, chemotaxis, sex myoblast migration, and muscle membrane extension; let-60 acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis; let-60 is expressed in neural, muscle, and hypodermal lineages.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24070
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          let-60 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            let-60 role
            let-60 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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