Version: 8.0.0
Date: Tue Jan 28 2025
lim-6
Caenorhabditis elegansWB:WBGene00002988
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lim-6

Species
Caenorhabditis elegans
Symbol
lim-6
Name
LIM domain family 6
Synonyms
  • CELE_K03E6.1
  • K03E6.1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defecation; regulation of gene expression; and uterus morphogenesis. Located in nucleus. Is expressed in several structures, including amphid neurons; excretory system; hermaphrodite gonad; nerve ring neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7 and nail-patella syndrome. Orthologous to several human genes including LMX1B (LIM homeobox transcription factor 1 beta).
WB Description
lim-6 encodes a LIM class homeodomain protein that contains two Zinc-finger-like LIM domains N-terminal to a predicted DNA-binding homeodomain; LIM-6 is predicted to function as a transcription factor whose activity is required for regulating uterine morphogenesis and specific aspects of terminal neuronal differentiation, including normal axonal morphology, full expression of UNC-25/glutamic acid decarboxylase in select GABAergic neurons, and repression of sensory receptor gene expression in the ASEL chemosensory neuron; LIM-6 is expressed in a group of nine chemosensory-, inter-, and motorneurons, uterine toroid cells, spermathecal junction cells, and the binucleate excretory gland cell.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24208
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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      Allele Synonyms
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            1.073M1.074M1.075M1.076M1.077M1.078M1.079M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            lim-6 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              lim-6 role
              lim-6 genetic perturbation
              Interactor gene
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