Gene

lin-22

Species
Caenorhabditis elegans
Symbol
lin-22
Name
abnormal cell LINeage 22
Synonyms
  • 4D656
  • CELE_Y54G2A.1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including intestine; nervous system; pharynx; seam cell; and uterus. Orthologous to human HES1 (hes family bHLH transcription factor 1).
WB Description
lin-22 encodes a basic helix-loop-helix (bHLH)-containing protein that is homologous to the Drosophila hairy/Enhancer of split transcriptional repressors; during postembryonic development, lin-22 activity is required for patterning of midbody epidermal and neuronal lineages.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10985
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.0200M3.0205M3.0210M3.0215M3.0220M3.0225M3.0230M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions