Version: 8.0.0
Date: Tue Jan 28 2025
lin-61
Caenorhabditis elegansWB:WBGene00003041
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

lin-61

Species
Caenorhabditis elegans
Symbol
lin-61
Name
abnormal cell LINeage 61
Synonyms
  • CELE_R06C7.7
  • R06C7.7
Biotype
protein coding gene
Automated Description
Predicted to enable chromatin binding activity and histone binding activity. Involved in vulval development. Located in chromatin and nucleus. Is expressed widely. Orthologous to several human genes including L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1).
WB Description
lin-61 encodes a protein that contains four malignant brain tumor (MBT) repeats and is similar to the human and mouse lethal (3) malignant brain tumor 2 [L(3)MBT2] proteins; LIN-61 is predicted to function in a transcriptional regulatory complex that may play a role in transcriptional repression during development; loss of lin-61 activity via RNAi and mutation indicates that LIN-61 is required for: 1) genome stability in the soma and germline, and 2) postembryonic developmental processes such as vulval development, in which lin-61 acts as a class B synthetic multivulval (SynMuv) gene and as a candidate transcriptional repressor of genes such at mat-3; LIN-61 is broadly expressed throughout development, from the one-cell embryo through adulthood, and localizes to nuclei.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          lin-61 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            lin-61 role
            lin-61 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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