Version: 8.0.0Date: Tue Jan 28 2025
Gene
lip-1
- Species
- Caenorhabditis elegans
- Symbol
- lip-1
- Name
- Lateral-signal-Induced Phosphatase 1
- Synonyms
- C05B10.1
- CELE_C05B10.1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of vulval development; and vulval cell fate specification. Located in plasma membrane. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; germ line; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to several human genes including DUSP6 (dual specificity phosphatase 6) and DUSP7 (dual specificity phosphatase 7).
- WB Description
- lip-1 encodes a mitogen-activated protein (MAP) kinase phosphatase homologous to the vertebrate dual specificity phosphatase MKP-3; during development, LIP-1 negatively regulates MAP kinase activity to control the extent of germline proliferation and oocyte meiotic cell cycle progression; lip-1 activity is also required redundantly with dep-1 to negatively regulate MAPK signaling during vulval induction; in addition, lip-1 is required for normal embryonic development; lip-1 expression begins during embryogenesis and continues through adulthood; expression is seen in most somatic cells and in germ cells of the pachytene region, transition zone and proximal-most region of the mitotic zone; in the pachytene region, LIP-1 is associated with the plasma membrane; in early L3 larvae, LIP-1 expression increases in secondary vulval precursor cells in a lin-12/Notch-dependent manner, suggesting that lip-1 may be a direct downstream target of lin-12-mediated signaling; interaction with the Notch pathway is further demonstrated by chromatin immunoprecipitation experiments showing that, in the germline, the lip-1 promoter region coprecipitates with LAG-3; germline lip-1 mRNA accumulation is negatively regulated by the FBF proteins (FBF-1 and FBF-2) that bind to the lip-1 3'UTR.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10159
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIV:6842958...6846011 + (3.05 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.