Version: 8.0.0
Date: Tue Jan 28 2025
mab-3
Caenorhabditis elegansWB:WBGene00003100
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mab-3

Species
Caenorhabditis elegans
Symbol
mab-3
Name
Male ABnormal 3
Synonyms
  • CELE_Y53C12B.5
  • Y53C12B.5
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including SMDVL; head neurons; intestine; ray neurons; and tail.
WB Description
mab-3 encodes a DM (Doublesex and MAB-3) domain-containing protein; during development, MAB-3 plays a role in several aspects of male development; specifically, genetic studies indicate that MAB-3 likely augments the functions of the MAB-5 and EGL-5 homeodomain proteins by acting as a transcriptional repressor of ref-1, which encodes a basic helix-loop-helix (bHLH) protein that negatively regulates expression of the LIN-32 proneural bHLH protein required for male sensory ray development; in addition, MAB-3 regulates yolk protein expression in the intestine; mab-3 expression in the intestine is negatively regulated by TRA-1A, the terminal protein in the sex determination pathway; a mab-3::GFP promoter fusion is expressed in neurons and hypodermal cells as well as in the intestine; expression of the male-specific form of Drosophila Doublesex can rescue mab-3-related defects in C. elegans.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12322
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mab-3 molecule type
          Interactor gene
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            Genetic Interactions

            mab-3 role
            mab-3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
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            Phenotype or trait
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