Gene

mel-11

Species
Caenorhabditis elegans
Symbol
mel-11
Name
Maternal Effect Lethal 11
Synonyms
  • C06C3.1
  • CELE_C06C3.1
Biotype
protein coding gene
Automated Description
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Involved in embryo development and embryonic body morphogenesis. Located in adherens junction and cytoplasm. Is expressed in several structures, including P1; P2; P3; P4; and hypodermal cell. Orthologous to several human genes including PPP1R12B (protein phosphatase 1 regulatory subunit 12B).
WB Description
mel-11 encodes the C. elegans ortholog of the vertebrate smooth muscle myosin-associated phosphatase regulatory subunit (PP-1M); during development, mel-11 activity negatively regulates embryonic morphogenesis, and genetic analysis suggests that mel-11 acts with let-502, and in parallel to fem-2, in one of two redundant pathways that ensures proper embryonic elongation; prior to elongation, MEL-11 localizes to the cytoplasm but once elongation begins, MEL-11 redistributes to the plasma membrane in response to LET-502 kinase activity; once morphogenesis is complete, MEL-11 relocalizes to the cytoplasm.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24179
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.359M9.360M9.361M9.362M9.363M9.364M9.365M9.366M9.367M9.368M9.369M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions