Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Involved in embryo development and embryonic body morphogenesis. Located in adherens junction and cytoplasm. Is expressed in several structures, including P1; P2; P3; P4; and hypodermal cell. Orthologous to several human genes including PPP1R12B (protein phosphatase 1 regulatory subunit 12B).
WB Description
mel-11 encodes the C. elegans ortholog of the vertebrate smooth muscle myosin-associated phosphatase regulatory subunit (PP-1M); during development, mel-11 activity negatively regulates embryonic morphogenesis, and genetic analysis suggests that mel-11 acts with let-502, and in parallel to fem-2, in one of two redundant pathways that ensures proper embryonic elongation; prior to elongation, MEL-11 localizes to the cytoplasm but once elongation begins, MEL-11 redistributes to the plasma membrane in response to LET-502 kinase activity; once morphogenesis is complete, MEL-11 relocalizes to the cytoplasm.