Gene

mlc-2

Species
Caenorhabditis elegans
Symbol
mlc-2
Name
Myosin Light Chain 2
Synonyms
  • C36E6.5
  • CELE_C36E6.5
Biotype
protein coding gene
Automated Description
Predicted to enable myosin heavy chain binding activity. Involved in several processes, including nematode larval development; regulation of muscle contraction; and regulation of nematode pharyngeal pumping. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 10. Orthologous to several human genes including MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7).
WB Description
mlc-2 encodes, along with mlc-1 and mlc-4, one of three C. elegans regulatory myosin light chains; MLC-2 is predicted to function as a regulator of myosin ATPase activity, and genetic studies indicate that MLC-2 is nearly essential in hermaphrodites for normal pharyngeal muscle function, but redundant with MLC-1, with which it is nearly identical, for proper bodywall muscle development; accordingly, loss of mlc-2 activity eventually results in larval lethality, as animals are not able to feed properly; mlc-2 mRNA is expressed in bodywall, pharyngeal, and vulval muscles.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23049
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            17.4558M17.4559M17.4560M17.4561M17.4562M17.4563M17.4564M17.4565M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            mlc-2 molecule type
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              Genetic Interactions

              mlc-2 role
              mlc-2 genetic perturbation
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