Version: 8.0.0Date: Tue Jan 28 2025
Gene
mpk-1
- Species
- Caenorhabditis elegans
- Symbol
- mpk-1
- Name
- MAP Kinase 1
- Synonyms
- CELE_F43C1.2
- F43C1.2
- Biotype
- protein coding gene
- Automated Description
- Enables MAP kinase activity. Involved in several processes, including determination of adult lifespan; intracellular signaling cassette; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including germ line; nervous system; oocyte; pharyngeal-intestinal valve; and rectal epithelium. Used to study cancer. Human ortholog(s) of this gene implicated in Noonan syndrome 13; Parkinson's disease; carcinoma (multiple); melanoma; and pulmonary hypertension. Orthologous to several human genes including MAPK1 (mitogen-activated protein kinase 1).
- WB Description
- mpk-1 encodes a mitogen-activated protein (MAP) kinase an ERK ortholog functioning in vulval cell fate specification, cell migration/guidance, defense against bacterial infection, and other processes; in proximal germline, sperm-dependent physiological MPK-1 activation results in phosphorylation based inactivation of NOS-3, FEM-CUL-2-mediated degradation of TRA-1 and the promotion of membrane organization during oogenesis; mpk-1 affect LET-60(Ras)-mediated induction of vulval cell fates, larval viability, morphology of the male spicules; both LIN-1 and LIN-31 act genetically downstream of mpk-1 with respect to vulval induction; MPK-1 is necessary for pachytene cell organization; mpk-1 mutants display germ cells arrested in pachytene; MPK-1 is necessary for the progression from distal to proximal pachytene; MPK-1 promotes pachytene progression, with the rise in dpMPK-1 triggering a transition from a distal pachytene to a proximal pachytene subtype; MPK-1 functions in the germline for meiotic prophase progression and gametogenesis; MPK-1 ERK signaling is necessary for the male germ cell fate; MPK-1 ERK has the nonessential function of promoting the proliferative germ cell fate; mpk-1 acts in combination with mek-2 to permit germ cell exit from the pachytene stage of first meiotic prophase; MPK-1 activation is temporally/spatially dynamic compared to relatively constant levels of total MPK-1.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24055
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIII:4216763...4228108 - (11.35 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.