Gene

nhl-1

Species
Caenorhabditis elegans
Symbol
nhl-1
Name
NHL (ring finger b-box coiled coil) domain containing 1
Synonyms
  • CELE_F54G8.4
  • F54G8.4
Biotype
protein coding gene
Automated Description
Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Is expressed in body wall musculature; non-striated muscle; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2).
WB Description
The nhl-1 gene encodes an RBCC protein, orthologous to the mammalian protein BERP; its C. elegans paralogs include ncl-1 and lin-41.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24104
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.148M9.149M9.150M9.151M9.152M9.153M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions