Version: 8.0.0Date: Tue Jan 28 2025
Gene
nhx-3
- Species
- Caenorhabditis elegans
- Symbol
- nhx-3
- Name
- Na/H eXchanger 3
- Synonyms
- C54F6.13
- CELE_C54F6.13
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in endomembrane system and membrane. Predicted to be active in plasma membrane. Is expressed in epithelial cell; hypodermis; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8 and end stage renal disease. Orthologous to human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5).
- WB Description
- nhx-3 encodes a sodium/proton exchanger expressed intracellularly (in elliptical, randomly distributed dots that might be multivesicular or Ward bodies) within hypodermal cells of the main body syncytium, socket cells, and the excretory pore cell, as well as (in adults) within uterine cells (probably ut1) in the region closest to the vulva, in spermathecal junction cells; nhx-3 has no obvious phenotype in mass RNAi screens; NHX-3 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton; speculatively, NHX-3 might enable hypodermis-specific secretion of cuticle or phagocytosis.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10110
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrV:7540890...7545523 - (4.63 kb)
- Assembly version
- WBcel235
- Viewer Help
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.