Version: 8.0.0
Date: Tue Jan 28 2025
nsf-1
Caenorhabditis elegansWB:WBGene00003818
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nsf-1

Species
Caenorhabditis elegans
Symbol
nsf-1
Name
NSF (N-ethylmaleimide sensitive secretion factor) homolog 1
Synonyms
  • CELE_H15N14.2
  • H15N14.2
Biotype
protein coding gene
Automated Description
Predicted to enable ATP hydrolysis activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Predicted to be active in Golgi stack. Is expressed in several structures, including egg-laying apparatus; excretory gland cell; nervous system; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase).
WB Description
Predicted to enable ATP hydrolysis activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in Golgi stack. Expressed in several structures, including egg-laying apparatus; excretory gland cell; intestinal cell; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Is an ortholog of human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23078
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
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          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            7.767M7.768M7.769M7.770M7.771M7.772M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nsf-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              nsf-1 role
              nsf-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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