Gene

nsy-1

Species
Caenorhabditis elegans
Symbol
nsy-1
Name
Neuronal SYmmetry 1
Synonyms
  • ask-1
  • CELE_F59A6.1
Biotype
protein coding gene
Automated Description
Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including AWC; hypodermis; intestine; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to several human genes including MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
WB Description
nsy-1 encodes a MAP kinase kinase kinase (MAP3K) that is orthologous to the mammalian apoptosis signal-regulating kinase (ASK) family of protein kinases; nsy-1 activity is required for chemotaxis, egg laying, pathogen response, and response to anoxia; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; NSY-1 interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11584
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.023M5.024M5.025M5.026M5.027M5.028M5.029M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nsy-1 molecule type
            Interactor gene
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              Genetic Interactions

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