Version: 8.0.0
Date: Tue Jan 28 2025
pak-1
Caenorhabditis elegansWB:WBGene00003911
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pak-1

Species
Caenorhabditis elegans
Symbol
pak-1
Name
P21-Activated Kinase family 1
Synonyms
  • C09B8.7
  • CELE_C09B8.7
Biotype
protein coding gene
Automated Description
Enables GTP binding activity and protein kinase activity. Involved in several processes, including gonad morphogenesis; hemidesmosome assembly; and inductive cell migration. Located in several cellular components, including axon; hemidesmosome; and neuronal cell body. Is expressed in several structures, including P5.p hermaphrodite; P6.p hermaphrodite; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in breast cancer; ductal carcinoma in situ; non-syndromic X-linked intellectual disability 30; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PAK2 (p21 (RAC1) activated kinase 2); and PAK3 (p21 (RAC1) activated kinase 3).
WB Description
pak-1 encodes, by alternative splicing, at least five isoforms of aputative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?),and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation);PAK-1 is required (redundantly with its paralog, MAX-2) for normalaxonal guidance of motoneurons, P cell migration, and locomotion, withmax-2(cy2);pak-1(ok448) double mutants phenotypically resembling unc-73or ced-10;mig-2 mutants; pak-1 is expressed in pharyngeal muscles, CANneurons, ventral cord motoneurons, migrating distal tip cells,developing uterus, B, Y, and T cells in the male tail, and vulval musclecells; by itself, the null pak-1(ok448) mutation has no known phenotype.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48015
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pak-1 molecule type
          Interactor gene
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            Genetic Interactions

            pak-1 role
            pak-1 genetic perturbation
            Interactor gene
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            Interactor role
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            Phenotype or trait
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