Version: 8.0.0Date: Tue Jan 28 2025
Gene
par-6
- Species
- Caenorhabditis elegans
- Symbol
- par-6
- Name
- abnormal embryonic PARtitioning of cytoplasm 6
- Synonyms
- CELE_T26E3.3
- T26E3.3
- Biotype
- protein coding gene
- Automated Description
- Enables protein kinase C binding activity and small GTPase binding activity. Involved in several processes, including establishment of mitotic spindle localization; gonad development; and polarity specification of anterior/posterior axis. Located in P granule and cell cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including AB; EMS; P0; Psub1; and excretory cell. Orthologous to several human genes including PARD6B (par-6 family cell polarity regulator beta).
- WB Description
- par-6 encodes a PDZ-domain-containing protein that is conserved in Drosophila and mammals; during development, maternally provided PAR-6 is required for establishing anterior-posterior polarity in the early C. elegans embryo; par-6 activity is also essential for determining proper apicobasal asymmetries associated with cell adhesion and gastrulation; PAR-6 localizes to the periphery of the newly fertilized embryo, and then becomes more prominent in the anterior periphery as well as the advancing cleavage furrow during the first mitosis; in germline precursors, PAR-6 localizes asymmetrically to sites that correspond to the future EMS and C blastomeres; in somatic cells, by the end of the four-cell stage, PAR-6 is seen as a 'cap' centered on the apical surface; in embryos, PAR-6 colocalizes with PAR-3 and is mutually dependent upon PAR-3 and PKC-3 for proper localization, suggesting that these proteins may act in a complex to establish embryonic polarity; PAR-6 localization is also dependent upon wild-type activity of par-4.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR14102
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:12669380...12674449 + (5.07 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.