Version: 8.0.0
Date: Tue Jan 28 2025
pkc-3
Caenorhabditis elegansWB:WBGene00004034
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pkc-3

Species
Caenorhabditis elegans
Symbol
pkc-3
Name
Protein Kinase C 3
Synonyms
  • CELE_F09E5.1
  • F09E5.1
Biotype
protein coding gene
Automated Description
Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including antifungal innate immune response; gonad development; and response to wounding. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Is expressed in several structures, including D; Psub4; enteric muscle; hypodermis; and pharyngeal-intestinal valve. Orthologous to human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta).
WB Description
pkc-3 encodes an atypical protein kinase that lacks a DAG binding domain; during early embryonic development, pkc-3 plays an essential role in establishing anterior-posterior polarity; PKC-3 localizes to the anterior periphery of the one-cell embryo in a manner dependent upon the PAR-3 PDZ domain-containing protein with which PKC-3 physically interacts; PKC-3 also localizes to the outer, apical surfaces of cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pkc-3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            pkc-3 role
            pkc-3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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