Version: 8.0.0
Date: Tue Jan 28 2025
pmk-2
Caenorhabditis elegansWB:WBGene00004056
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pmk-2

Species
Caenorhabditis elegans
Symbol
pmk-2
Name
P38 Map Kinase family 2
Synonyms
  • CELE_F42G8.3
  • F42G8.3
Biotype
protein coding gene
Automated Description
Enables MAP kinase activity. Involved in intracellular signal transduction and response to osmotic stress. Located in cytoplasm. Is expressed in ganglia; gonad; intestine; and somatic nervous system. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to several human genes including MAPK11 (mitogen-activated protein kinase 11) and MAPK14 (mitogen-activated protein kinase 14).
WB Description
The pmk-2 gene encodes a homolog of p38, a type of mitogen-activated protein kinase (MAPK) that in mammals is generally activated by diverse cellular stresses and ligands.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24055
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pmk-2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            pmk-2 role
            pmk-2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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