Gene

myrf-1

Species
Caenorhabditis elegans
Symbol
myrf-1
Name
myelin regulatory factor related 1
Synonyms
  • CELE_F59B10.1
  • F59B10.1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode larval development. Located in basal part of cell and endoplasmic reticulum. Is expressed in several structures, including excretory system; muscle cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to several human genes including MYRFL (myelin regulatory factor like).
WB Description
myrf-1 encodes a protein with a glutamine/asparagine-rich domain, orthologous to human MYRF (myelin regulatory factor); in C. elegans, MYRF-1 activity is required for regulation of the molting cycle, specifically the completion of larval molts and cessation of molting in reproductively mature adult animals; a MYRF-1::GFP fusion protein is expressed in a wide variety of cells and tissues, including neurons, secretory cells, and hypodermal seam cells, but is not seen in the hyp7 syncytial hypodermis; expression begins in the comma stage of embryogenesis and persists through adulthood; full length C. elegans MYRF-1::GFP localizes to the cytoplasm where it partially overlaps with the endoplasmic reticulum; MYRF-1 contains a well-conserved paralog in the C. elegans genome, MYRF-2, encoded by F21A10.2.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13029
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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10.4970M10.4975M10.4980M10.4985M10.4990M10.4995M10.5000M10.5005M10.5010M10.5015M10.5020M10.5025M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions