Version: 8.0.0
Date: Tue Jan 28 2025
pqn-59
Caenorhabditis elegansWB:WBGene00004143
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pqn-59

Species
Caenorhabditis elegans
Symbol
pqn-59
Name
Prion-like-(Q/N-rich)-domain-bearing protein 59
Synonyms
  • CELE_R119.4
  • prp-1
Biotype
protein coding gene
Automated Description
Predicted to be active in cytoplasm and nucleus. Is expressed widely. Orthologous to several human genes including UBAP2L (ubiquitin associated protein 2 like).
WB Description
pqn-59 encodes a protein containing a glutamine/asparagine (Q/N)-rich domain and similarity to the vertebrate ubiquitin-associated proteins UBAP2 and UBAP2L; microarray experiments indicate that pqn-59 is expressed maternally and embryonically and in situ hybridization studies show that pqn-59 mRNA exhibits strong germline expression; loss of pqn-59 activity via RNAi in a wild-type background results in eggs that are smaller than normal, embryonic and larval lethality, and animals that are sick with smaller than normal brood sizes; pqn-59(RNAi) in an rrf-3 background additionally results in uncoordinated locomotion, consistent with the presence of pqn-59 transcripts in motor neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16308
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          pqn-59 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            pqn-59 role
            pqn-59 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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