Version: 8.0.0
Date: Tue Jan 28 2025
swsn-4
Caenorhabditis elegansWB:WBGene00004204
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

swsn-4

Species
Caenorhabditis elegans
Symbol
swsn-4
Name
SWI/SNF nucleosome remodeling complex component 4
Synonyms
  • CELE_F01G4.1
  • F01G4.1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Involved in gonad development. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; tail; and vulval cell. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; Nicolaides-Baraitser syndrome; blepharophimosis-impaired intellectual development syndrome; carcinoma (multiple); and rhabdoid tumor predisposition syndrome 2. Orthologous to human SMARCA2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2) and SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
WB Description
swsn-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; swsn-4 is probably required during mitosis of the T cells for asymmetric cell division.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10799
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          swsn-4 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            swsn-4 role
            swsn-4 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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